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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: PDIA1_HUMAN




USC-OGP 2-DE database:  PDIA1_HUMAN

PDIA1_HUMAN


General information about the entry
View entry in simple text format
Entry namePDIA1_HUMAN
Primary accession numberP07237
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; AltName: Full=p55; Flags: Precursor;.
Gene nameName=P4HB
Synonyms=ERBA2L, PDI, PDIA1, PO4DB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info 		 
PLATELET_4-5

MAP LOCATIONS:
pI=4.71; Mw=56520
pI=4.70; Mw=56395
pI=4.73; Mw=56271
pI=4.74; Mw=56271



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info 		 
PLATELET_4-7

MAP LOCATIONS:
pI=4.72; Mw=57608



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info 		 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=4.85; Mw=55709
pI=6.34; Mw=55360
pI=6.17; Mw=55186

Cross-references
UniProtKB/Swiss-ProtP07237; PDIA1_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry namePDIA1_HUMAN
Primary accession numberP07237
Secondary accession number(s) B2RDQ2 P30037 P32079 Q15205 Q6LDE5
Sequence was last modified on November 1, 1997 (version 3)
Annotations were last modified on March 15, 2017 (version 223)
Name and origin of the protein
DescriptionRecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1; AltName: Full=Cellular thyroid hormone-binding protein; AltName: Full=Prolyl 4-hydroxylase subunit beta; AltName: Full=p55; Flags: Precursor;
Gene nameName=P4HB
Synonyms=ERBA2L, PDI, PDIA1, PO4DB
Encoded onName=P4HB; Synonyms=ERBA2L, PDI, PDIA1, PO4DB
Keywords3D-structure; Acetylation; Cell membrane; Chaperone; Complete proteome; Craniosynostosis; Direct protein sequencing; Disease mutation; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Osteogenesis imperfecta; Phosphoprotein; Redox-active center; Reference proteome; Repeat; Signal.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX05130; CAA28775.1; -; mRNA
EMBLJ02783; AAA61169.1; -; mRNA
EMBLM22806; AAC13652.1; -; Genomic_DNA
EMBLM22803; AAC13652.1; JOINED; Genomic_DNA
EMBLM22804; AAC13652.1; JOINED; Genomic_DNA
EMBLM22805; AAC13652.1; JOINED; Genomic_DNA
EMBLAK315631; BAG37999.1; -; mRNA
EMBLCH471099; EAW89690.1; -; Genomic_DNA
EMBLBC010859; AAH10859.1; -; mRNA
EMBLBC029617; AAH29617.1; -; mRNA
EMBLBC071892; AAH71892.1; -; mRNA
EMBLS37207; AAB22262.2; -; Genomic_DNA
EMBLX07077; CAA30112.1; -; mRNA
CCDSCCDS11787.1; -; .
PIRA31913; ISHUSS; .
RefSeqNP_000909.2; NM_000918.3; .
UniGeneHs.464336; -; .
PDB1BJX; NMR; -; A=136-245
PDB1MEK; NMR; -; A=18-137
PDB1X5C; NMR; -; A=368-475
PDB2BJX; NMR; -; A=136-245
PDB2K18; NMR; -; A=135-357
PDB3BJ5; X-ray; 2.20 A; A=230-368
PDB3UEM; X-ray; 2.29 A; A=137-479
PDB4EKZ; X-ray; 2.51 A; A=18-479
PDB4EL1; X-ray; 2.88 A; A/B=18-479
PDB4JU5; X-ray; 2.28 A; A/B=135-367
PDBsum1BJX; -; .
PDBsum1MEK; -; .
PDBsum1X5C; -; .
PDBsum2BJX; -; .
PDBsum2K18; -; .
PDBsum3BJ5; -; .
PDBsum3UEM; -; .
PDBsum4EKZ; -; .
PDBsum4EL1; -; .
PDBsum4JU5; -; .
ProteinModelPortalP07237; -; .
SMRP07237; -; .
BioGrid111073; 129; .
DIPDIP-32979N; -; .
IntActP07237; 65; .
MINTMINT-4999403; -; .
STRING9606.ENSP00000327801; -; .
BindingDBP07237; -; .
ChEMBLCHEMBL5422; -; .
DrugBankDB03615; Ribostamycin; .
iPTMnetP07237; -; .
PhosphoSitePlusP07237; -; .
SwissPalmP07237; -; .
BioMutaP4HB; -; .
DMDM2507460; -; .
DOSAC-COBS-2DPAGEP07237; -; .
OGPP07237; -; .
REPRODUCTION-2DPAGEIPI00010796; -; .
REPRODUCTION-2DPAGEP07237; -; .
SWISS-2DPAGEP07237; -; .
EPDP07237; -; .
MaxQBP07237; -; .
PaxDbP07237; -; .
PeptideAtlasP07237; -; .
PRIDEP07237; -; .
TopDownProteomicsP07237; -; .
DNASU5034; -; .
EnsemblENST00000331483; ENSP00000327801; ENSG00000185624; .
GeneID5034; -; .
KEGGhsa:5034; -; .
UCSCuc002kbn.2; human; .
CTD5034; -; .
DisGeNET5034; -; .
GeneCardsP4HB; -; .
HGNCHGNC:8548; P4HB; .
HPACAB012463; -; .
HPAHPA018884; -; .
MalaCardsP4HB; -; .
MIM112240; phenotype; .
MIM176790; gene; .
neXtProtNX_P07237; -; .
OpenTargetsENSG00000185624; -; .
PharmGKBPA32876; -; .
eggNOGKOG0190; Eukaryota; .
eggNOGCOG0526; LUCA; .
GeneTreeENSGT00860000133691; -; .
HOGENOMHOG000162459; -; .
HOVERGENHBG005920; -; .
InParanoidP07237; -; .
KOK09580; -; .
OMAIEKYVDP; -; .
OrthoDBEOG091G08WM; -; .
PhylomeDBP07237; -; .
TreeFamTF106381; -; .
BRENDA5.3.4.1; 2681; .
ReactomeR-HSA-1650814; Collagen biosynthesis and modifying enzymes; .
ReactomeR-HSA-174800; Chylomicron-mediated lipid transport; .
ReactomeR-HSA-3299685; Detoxification of Reactive Oxygen Species; .
ReactomeR-HSA-5358346; Hedgehog ligand biogenesis; .
ReactomeR-HSA-8866423; VLDL biosynthesis; .
ChiTaRSP4HB; human; .
EvolutionaryTraceP07237; -; .
GeneWikiP4HB; -; .
GenomeRNAi5034; -; .
PMAP-CutDBP07237; -; .
PROPR:P07237; -; .
ProteomesUP000005640; Chromosome 17; .
BgeeENSG00000185624; -; .
CleanExHS_P4HB; -; .
ExpressionAtlasP07237; baseline and differential; .
GenevisibleP07237; HS; .
GOGO:0005783; C:endoplasmic reticulum; IDA:UniProtKB; .
GOGO:0034663; C:endoplasmic reticulum chaperone complex; IEA:Ensembl; .
GOGO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; .
GOGO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB; .
GOGO:0009897; C:external side of plasma membrane; IDA:UniProtKB; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005576; C:extracellular region; NAS:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0016222; C:procollagen-proline 4-dioxygenase complex; IDA:MGI; .
GOGO:0005178; F:integrin binding; IPI:UniProtKB; .
GOGO:0004656; F:procollagen-proline 4-dioxygenase activity; TAS:ProtInc; .
GOGO:0003756; F:protein disulfide isomerase activity; IDA:CACAO; .
GOGO:0046982; F:protein heterodimerization activity; IDA:UniProtKB; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0045454; P:cell redox homeostasis; IEA:InterPro; .
GOGO:0071456; P:cellular response to hypoxia; IMP:BHF-UCL; .
GOGO:0042158; P:lipoprotein biosynthetic process; TAS:Reactome; .
GOGO:0018401; P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline; IDA:MGI; .
GOGO:0046598; P:positive regulation of viral entry into host cell; IMP:UniProtKB; .
GOGO:0006457; P:protein folding; IBA:GO_Central; .
GOGO:1902175; P:regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IMP:BHF-UCL; .
GOGO:0034976; P:response to endoplasmic reticulum stress; IMP:BHF-UCL; .
GOGO:0000302; P:response to reactive oxygen species; TAS:Reactome; .
Gene3D3.40.30.10; -; 4; .
InterProIPR005788; Disulphide_isomerase; .
InterProIPR005792; Prot_disulphide_isomerase; .
InterProIPR012336; Thioredoxin-like_fold; .
InterProIPR017937; Thioredoxin_CS; .
InterProIPR013766; Thioredoxin_domain; .
PfamPF00085; Thioredoxin; 2; .
SUPFAMSSF52833; SSF52833; 4; .
TIGRFAMsTIGR01130; ER_PDI_fam; 1; .
TIGRFAMsTIGR01126; pdi_dom; 2; .
PROSITEPS00014; ER_TARGET; 1; .
PROSITEPS00194; THIOREDOXIN_1; 2; .
PROSITEPS51352; THIOREDOXIN_2; 2; .


USC-OGP 2-DE database image

Gateways to other related servers

Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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